ISCT Webinar: Towards Bioengineered Control of Cell Fate Post Transplantation
Organized by the ISCT Commercialization Committee
Please open the PDF slide and click the link on the first page to access the Digital Recording.
Date: November 20th, 2013
Time: 12pm ET to 1:00pm ET
Chair: Aleksander Francki, PhD, Senior Principal Scientist, Celgene Cellular Therapeutics, USA
Speaker(s): Jeffrey M. Karp, PhD, Associate Professor of Medicine, Brigham and Women's Hospital, Harvard Medical School, USA
About the Webinar:
Control of cell fate and its extracellular environment is critical for tissue regeneration and cell therapy. This talk will explore methods to enhance the engraftment of systemically infused stem cells through engineering the cell surface to induce a robust rolling response. This approach is based on leukocytes ability to target tissues via specific interactions with the vascular endothelium. In addition, a strategy to engineer cells with an intracellular depot of phenotype altering agents will be described that can be used for drug delivery or programming cell fate via both intracrine-, paracrine-, and endocrine-like mechanisms. The talk will also examine the potential of cell surface sensors that can be used to detect signals within the cellular nano-environment with unprecedented spatial and temporal resolution. This should be useful for monitoring the cell secretome following transplantation, for drug discovery and for elucidating niche biology in vivo.